Sop for Chromatographic practices and system suitability Sop for trend analysis of finished products Sop for collection storage and disposal of control samples Sop for non conformance of RM PM and finished product Sop for approval and rejection of packaging materials Sop for operation and calibration of friability test apparatus Sop for sampling of intermediates and finished products Sop for sampling of packaging materials PM Sop for Control of issuance of record of analysis green sheets Sop for Retesting and resampling of raw materials Sop for operation of rub proofness tester Sop for operation and calibration of shore hardness tester Sop for Operation and calibration of bulk density apparatus Sop for Operation and calibration uv cabinet Sop for destruction of analytical samples after testing and control samples Sop for operation and calibration of serological water bath Sop for Operation and calibration of gas liquid chromatograph Sop for Operation and calibration of atomic absorption spectrophotometer Sop for operation and calibration of total organic carbon analyzers Storage : Store in glass bottles having well fitted, suitable stoppers. Precaution – Check the physical appearance and fungal growth, sedimentation or change in color.ĥ. (if not used within 15 days solution has to be standardized again just before use.)Ĥ. Validity: 1 Month from the date of preparation and Re-Standardisation after15 days and when required. This solution must be standardized frequently every 15 days.ģ. Calculate the molarity of the solution by below given formula.Įach ml of 1 M Sodium Hydroxide is equivalent to 0.2042g of C8H5KO4.(potassium hydrogen phthalate)ĭetermine the molarity in triplicate and calculate the average value where the variation is not more than 0.2%. Note down the volume of sodium hydroxide solution consumed during titration. Add 0.1ml of phenolphthalein solution and titrate with the sodium hydroxide solution until a permanent pink color is produced. Weigh accurately about 5g of potassium hydrogen phthalate (previously powdered and dried at 120oC for 2 hours) and transfer to a conical flask. Dissolve in sufficient purified water and make up to the mark with purified water.Īs per requirement (consumption history) prepare suitable amount of volumetric solution accordingly. Weigh accurately about 42g of Sodium Hydroxide and transfer to a 1000ml volumetric flask. When KHP is used as a basimetric standard (e.g., in standardization of Perchloric Acid in Glacial Acetic Acid), Methyl Violet or Crystal Violet indicator is commonly used.Preparation and standardization of 1 M Sodium Hydroxide solution
Phenolphthalein Indicator is most commonly used in titrations where KHP is used as an acidimetric standard to standardize solutions of bases. It is also used in the quality control of Potassium Hydroxide and Sodium Hydroxide solutions, and in the standardization of Perchloric Acid in Glacial Acetic Acid. KHP is used in the manufacture of buffers, organic carbon standards, acidimetric standards and other products. RICCA CHEMICAL COMPANY uses large quantities of KHP in the manufacture and quality control of its products. Potassium Hydrogen Phthalate (KHP) is a classic primary standard substance in that it is readily available in high purity is relatively inexpensive is easy to dry is neither hygroscopic, oxidized by air, nor affected by Carbon Dioxide (thus making it easy to weigh out) does not undergo decomposition during storage has a relatively high equivalent weight (thus reducing errors when weighed to 0.1 mg precision) is readily soluble in water and is stoichiometric and instantaneous in reactions.
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